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KMID : 1161520120160030215
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Animal Cells and Systems
2012 Volume.16 No. 3 p.215 ~ p.223
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Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells
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Kim Hyo-Jeong
Yoon Taek-Joon
Lee Sung-Won
Yun Dae-Sun
Kim Ji-Yeon
Shin Kwang-Soon
Park Se-Ho
Hong Seok-Mann
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Abstract
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Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.
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KEYWORD
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heat-killed tumor cells, dendritic cells, interleukin 12
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